A More Powerful Way to Develop Therapeutics?

Jul 21, 2016
Author: 
Heidi Singer

A University of Toronto scientist has developed a new method for identifying the raw ingredients necessary to build ‘biologics’, a powerful class of medications that has revolutionized treatment of diseases like rheumatoid arthritis and some cancers.

Associate Professor Philip KimAssociate Professor Philip Kim

Biologics are a type of drug that results from the high-tech manipulation of our own proteins, as opposed to more traditional drugs built from synthetic chemicals. Because of their success so far, scientists are racing to create new biologics – and now, a University of Toronto researcher has developed a way to make that process more powerful.

Philip M. Kim, an associate professor in U of T’s Donnelly Centre for Cellular and Biomolecular Research, combined high-tech computer simulation and high-throughput laboratory experiments to create what he hopes will be the most effective way to discover the proteins that are key to new biologics. His research was published online in the journal Science Advances on July 20, 2016.

“A large fraction of new therapeutics these days involve engineered proteins that latch onto a drug target, for instance on a cancer cell,” says Kim, also of the departments of Molecular Genetics and Computer Science. “Finding a protein that effectively binds to a target can feel like looking for a needle in a haystack. Our method should open up new opportunities to find those key proteins – and make a major impact on the development of new biologics.”

Under the traditional approach to developing a biologic, researchers identify a protein of interest and then test billions of variants, either randomly generated or from a natural source, hoping to find an effective binder. But these methods allow very little control over where and how the protein performs this crucial function on its target – a major factor in its effectiveness.

Kim and his team took a different approach. They used a computer to simulate the binding process, and then designed proteins that would work on the target. This type of theoretical approach has been in development for several decades, but is still not effective enough. So Kim combined the best of both methods. Instead of randomly creating massive libraries of variants, as with the traditional approach, he used computer modelling to generate a smaller, but intelligently designed repertoire of variants. Designing each variant allows for the tight control of all its properties, in contrast to conventional approaches.

“We showed that this method gives you binders that are somewhat stronger than what you get with the conventional approach,” says Kim. “The much smaller library also solves many technical problems, and we can screen for new, previously unscreenable, targets. It’s a very exciting time for cancer research, and for biologics.”

For Kim, the next step is to produce proteins that are important to certain types of cancer, but have not been screened before due to the difficulty producing them. 

Oct 16 – Jun 18
CPD Foundations
Workshop/Seminar | 12:00pm–1:30pm
Jan 12 Making the Dead Talk
Symposium | 9:00am–4:45pm
Jan
14 – 18
Psychiatry Refresher Program
| 9:00am–5:00pm
Jan 16 – May 1
Deepening Narrative Competence Program
Course | 4:15pm
Jan 16 Deepening Narrative Competence - Part Two
Course | 6:00pm–8:00pm
Jan 18 Advances in the Molecular Classification of Brain Tumours
Grand Rounds | 8:00am–9:00am
Jan
18 – 19
Inaugural Joint Cardiovascular-Diabetes Symposium
Symposium | 8:00am–5:15pm

Tweets

UofT Medicine
@uoftmedicine
RT : It's ! 🍁 Earlier this year, we got a unique look at the sweet stuff as we took the first imag… https://t.co/azN9NfBgvk
UofT Medicine
@uoftmedicine
Rates of cirrhosis are increasing fastest among young adults, study finds https://t.co/LXaffkehtF https://t.co/gLMa2bdmhg
UofT Medicine
@uoftmedicine
Language barriers can limit access to health care, which means patients may delay seeking care until the problem be… https://t.co/sM2M4UQCPx

UofTMed Magazine

Have we lost the art of dying?

Sign up for your free digital copy.
Back to Top