STAGE International Speaker Seminar Series (ISSS) with Dr. Clare Turnbull
Join us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with
Clare Turnbull, MD, PhD, FRCP, FRCPath, MFPH, DCH, MA, MSc (Epidemiology)
Professor of Medical Genomics, Institute of Cancer Research, London
Honorary Consultant in Clinical Cancer Genetics, Royal Marsden NHS Foundation Trust, London
Honorary Consultant in Public Health Medicine, Public Health England, London
Talk Title: Breast Cancer Susceptibility Genetics: expansion of testing and emerging challenges
As optimism has waned that ‘precision-oncology’ will be panacea for decreasing the bulk cancer-related mortality associated with most common solid tumors, attention has re-focused on cancer prevention and early detection. Any such strategy is likely a priori to have more impact if targeted to those at the highest risk of developing cancer, namely the genetically predisposed. With recent technology advances facilitating cheap high throughput sequencing, and massive political imperative to leverage ‘the power of genomics’ to rescue us from the rocketing cost of healthcare, pressure for delivery of results in cancer susceptibility genetics is unprecedented. I shall discuss leverageable opportunities for expansion of polygenic and monogenic testing for breast cancer genetic susceptibility along with the challenges of complex genomic architecture, risk, and variant pathogenicity.