CIHR Transitional Open Operating Grant Program - 2015

CIHR Transitional Open Operating Grant Program -  2015

Gerald Harvey Anderson

Campus

Department of Nutritional Sciences

Food intake control in children

                      640,500

Paul Hamel

Campus

Department of Laboratory Medicine & Pathobiology

Role of distinct modes of Hedgehog-signaling during the PI3K-dependent transformation of the mammary gland

                      710,161

Mary L’Abbe

Campus

Department of Nutritional Sciences

Food EPI - Assessing the food policy environment in Canada

                      356,551

Philip Marsden

Campus

Department of Medicine

Regulation of endothelial gene expression by epigenetic signalling pathways

                      603,900

Jason Moffat

Campus

Donnelly Centre

Genome-scale discovery and classification of functional genetic elements that drive cancer cell proliferation with ultracomplex CRISPR-Cas libraries

                      891,656

Justin Nodwell

Campus

Department of Biochemistry

Chemically-assisted discovery and investigation of antifungal drug leads

                      887,380

Beverley Orser

Campus

Department of Anesthesia

The role of astrocytic GABA-A receptors in postanesthetic memory deficits

                      976,055

David Riddick

Campus

Department of Pharmacology & Toxicology

Cytochrome P450 suppression by environmental toxicants: mechanisms and consequences

                      410,886

Mikko Taipale

Campus

Donnelly Centre

Systematic characterization of the Hsp70-regulated proteostasis network

                      971,724

Brendan Andrade

Centre for Addiction and Mental Health

Department of Psychiatry

Personalizing Psychosocial Intervention for Children with Oppositional-Defiant Disorder

                      505,435

Ariel Graff-Guerrero

Centre for Addiction and Mental Health

Department of Psychiatry

The role of Glutathione in Glutamatergic system dysregulation in Treatment-Resistant Schizophrenia

                      787,713

Nathan Kolia

Centre for Addiction and Mental Health

Department of Psychiatry

Investigating the Endocannabinoid System in Antisocial and Borderline Personality Disorder with Persistent Violence

                      352,810

Daniel Mueller

Centre for Addiction and Mental Health

Department of Psychiatry

Development, validation and benefits of a genetic risk model for antipsychotic-induced weight gain

                      704,869

Pablo Rusjan

Centre for Addiction and Mental Health

Department of Psychiatry

In-vivo Imaging of Neuroinflammation in Autism Spectrum Disorder

                      647,045

John Brumell

Hospital for Sick Children

Department of Molecular Genetics

Studies of novel IBD-associated genes and their impact on innate immunity

                      683,078

Brian Ciruna

Hospital for Sick Children

Department of Molecular Genetics

Novel mechanisms underlying ciliogenesis, planar cell polarity and cystic kidney disease

                      779,402

Brian Ciruna

Hospital for Sick Children

Department of Molecular Genetics

Investigating the link between cilia function and adolescent idiopathic scoliosis

                      770,676

Peter Dirks

Hospital for Sick Children

Department of Surgery

Functional and genomic clonal analysis of human glioblastoma

                      932,770

Johann Hitzler

Hospital for Sick Children

Department of Paediatrics

Mechanisms and Risk Stratification for Treatment of Acute Myeloid Leukemia in Children with Down syndrome

                      773,060

Nicola Jones

Hospital for Sick Children

Department of Paediatrics

Role of autophagy in Helicobacter pylori infection and disease

                      865,316

Ran Kafri

Hospital for Sick Children

Department of Molecular Genetics

Cell size specification in normal and malignant populations

                      723,978

David Kaplan

Hospital for Sick Children

Department of Molecular Genetics

Establishment and maintenance of adult neural stem cell pools

                      890,980

Catherine Jane McGlade

Hospital for Sick Children

Department of Medical Biophysics

Function and regulation of Numb protein isoforms in cancer

                      817,497

Steven P. Miller

Hospital for Sick Children

Department of Paediatrics

Cardiovascular Physiology and Brain Development In Newborns with Congenital Heart Disease

                   1,008,289

Paul Pencharz

Hospital for Sick Children

Department of Paediatrics

Use of indicator acid oxidation to determine amino acid requirement

                      731,560

Lisa Robinson

Hospital for Sick Children

Department of Paediatrics

Slit-Robo Signalling in Atherogenesis

                      762,836

Michael Salter

Hospital for Sick Children

Department of Physiology

P2 purinoceptors in the spinal dorsal horn

                      977,820

Margot Taylor

Hospital for Sick Children

Department of Paediatrics

Understanding the thoughts and emotions of others: neuroimaging measures of typical and atypical development

                      648,513

Dat Tran

Hospital for Sick Children

Department of Paediatrics

Vitamin D and related biomarkers as predictors of severe influenza infection in children

                      135,210

Theodore Brown

Mount Sinai Hospital

Department of Obstetrics & Gynecology

Impact of VEPH1 on cancer associated signaling pathways in the promotion of ovarian cancer

                      791,655

Sabine Cordes

Mount Sinai Hospital

Department of Molecular Genetics

Analyzing the roles of the Gumby/Fam105b linear deubiquitinase in development and disease

                      946,296

Joseph Culotti

Mount Sinai Hospital

Department of Molecular Genetics

Axon Guidance and Cell Migration Mechanisms in C. elegans

                      613,435

Daniel Drucker

Mount Sinai Hospital

Department of Medicine

Molecular and cellular mechanisms of dipeptidyl peptidase-4 action

                      415,554

Rita Kandel

Mount Sinai Hospital

Department of Laboratory Medicine & Pathobiology

Tissue engineering an intervertebral disc replacement

                      768,657

Karel O'Brien

Mount Sinai Hospital

Department of Paediatrics

Association of parent-infant interaction and chronic stress at 8 and 18 months of age with child behaviour following Family Integrated Care (FICare) in the neonatal intensive care unit

                      201,000

Laurence Pelletier

Mount Sinai Hospital

Department of Molecular Genetics

Primary cilia biogenesis and function in human cells

                      826,589

Sunit Das

St. Michael's Hospital

Department of Surgery

Targeting bevacizumb resistance via LIVE-mediated vascular mimicry in glioblastoma

                      545,268

Navindra Persaud

St. Michael's Hospital

Department of Family and Community Medicine

Does regular xylitol use reduce the number of acute otitis media episodes in young children? A pragmatic RCT

                      677,429

Emil Schemitsch

St. Michael's Hospital

Department of Surgery

Operative versus Non-operative Treatment of Acute Unstable Chest Wall Injuries: A Multi-Centred Randomized Controlled Trial

                      682,546

Katalin Szaszi

St. Michael's Hospital

Department of Surgery

Regulation and functions of Rho guanine nucleotide exchange factors in tubular epithelial cells

                      645,653

Subodh Verma

St. Michael's Hospital

Department of Surgery

In vivo and translational role of endothelial autophagy in the regulation of vascular diseases

                      612,036

Ron Wald

St. Michael's Hospital

Department of Medicine

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

                   1,177,472

Darren Yuen

St. Michael's Hospital

Department of Medicine

Targeting TAZ and YAP: a new approach to anti-fibrotic therapy in the kidney

                      724,329

Clare Atzema

Sunnybrook Health Sciences Centre

Department of Medicine

Follow-up Care After a Visit to the Emergency Department: Assessing the Impact in Patients with Chronic Disease Exacerbations

                         69,506

Sandra Black

Sunnybrook Health Sciences Centre

Department of Medicine

Cohort to illuminate Neurodegeneration, Genetics, Imaging Associations and Leukoaraiosis (CONGENIAL)

                      919,405

Curtis Caldwell

Sunnybrook Health Sciences Centre

Department of Medical Imaging

Personalizing Radionuclide Therapy of Neuroendocrine Tumours

                      433,320

James Carlyle

Sunnybrook Health Sciences Centre

Department of Immunology

Molecular mechanisms of natural killer (NK) and innate lymphoid cell (ILC) development and function in health and disease

                      672,628

Jorge Filmus

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

The role of Glypican-6 in Recessive Omodysplasia

                      700,525

Robert Fowler

Sunnybrook Health Sciences Centre

Department of Medicine

Regional and temporal variations in incidence, prevalence and outcomes of critical illness among pregnant and post-partum women and newborns in Canada

                         46,415

Kullervo Hynynen

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Feasibility of focused ultrasound treatment of deep vein thrombosis

                      722,716

Jacques Lee

Sunnybrook Health Sciences Centre

Department of Medicine

ED Ultrasonographic Regional Anesthesia to Prevent Incident Delirium in Hip Fracture Patients (EDU_RAPID)

                      561,326

Neil Rector

Sunnybrook Health Sciences Centre

Department of Psychiatry

Neurodevelopmental Risk for Anxiety and Mood Disorders in Pregnancy and the Post-Partum Period

                   1,005,787

Damon Scales

Sunnybrook Health Sciences Centre

Department of Medicine

The NEUROlogically-impaired extubation Timing Trial (NEURO-ETT)

                      880,404

Damon Scales

Sunnybrook Health Sciences Centre

Department of Medicine

Paramedic Initiated Treatment of Sepsis Trial in Out-of-hospital Patients (PITSTOP)

                      900,554

Robert Screaton

Sunnybrook Health Sciences Centre

Department of Biochemistry

Novel Regulators of Mitochondrial Dynamics

                      734,129

Peter Backx

UHN - Toronto General Hospital

Department of Physiology

Next generation arrhythmia modeling: the role of pluripotent stem cells and the future of personalized medicine

                      668,535

Myron Cybulsky

UHN - Toronto General Hospital

Department of Laboratory Medicine & Pathobiology

Inflammatory functions of lipid-laden macrophages in early atherosclerosis

                      718,432

Housheng He

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Epigenetic Regulation and Noncoding RNA in Prostate Cancer Progression

                      695,400

Rama Khokha

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Discovery of Novel Therapeutic Targets in Osteosarcoma

                      802,985

Philippe Monnier

UHN - Toronto Western Hospital

Department of Physiology

Novel strategies to promote CNS regeneration

                      765,944

Kumaraswamy Nanthakumar

UHN - Toronto General Hospital

Department of Medicine

Translational Studies of RyR2 Modulation for Human Ventricular Fibrillation

                      625,834

Linda Penn

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Targeting the Mevalonate Pathway and its Restorative Feedback Loop

                      731,950

Lianne Singer

UHN - Toronto General Hospital

Department of Medicine

New approaches to evaluating frailty in solid organ transplantation

                      452,660

Paaladinesh Thavendiranathan

UHN - Toronto General Hospital

Department of Medicine

Evaluation of Myocardial changes during BReast Adenocarcinoma therapy to detect Cardiotoxicity Earlier with MRI- The EMBRACE-MRI Study

                      641,160

Robert Weersink

UHN - Princess Margaret Hospital

Department of Radiation Oncology

Improving Target Definition in Radiation Therapy Planning by the Spatial Registration of Optical Endoscopy Imaging with Volumetric Imaging

                      280,582

Minna Nancy Woo

UHN - Toronto General Hospital

Department of Medicine

Dissecting inflammatory and apoptotic signaling in adipocytes

                      699,710

Brad Wouters

UHN - Princess Margaret Hospital

Department of Radiation Oncology

Targeting hypoxia in pancreatic cancer through the unfolded protein response

                      738,505

Li Zhang

UHN - Toronto General Hospital

Department of Laboratory Medicine & Pathobiology

Establishing donor-specific transplantation tolerance by harnessing DN regulatory T cells

                      676,395

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