CIHR Project Grants - 1st Live Pilot: Spring 2016

CIHR Project Grants - 1st Live Pilot: Spring 2016

Deirdre R. Dawson

Baycrest Centre

Occupational Science & Occupational Therapy

Preventing cognitive and functional decline among seniors at risk: A community-based randomized controlled trial

        1,191,091

Anne S. Bassett

Centre for Addiction and Mental Health

Department of Psychiatry

Predicting occurrence and lifetime expression of a major recurrent copy number variation

        1,127,640

Daniel M. Blumberger

Centre for Addiction and Mental Health

Department of Psychiatry

Neuroimaging Predictors of Response to rTMS in Late-Life Depression

           569,552

Sean A. Kidd

Centre for Addiction and Mental Health

Department of Psychiatry

Testing the Effectiveness of a Brief, Peer Support Intervention to Facilitate Transition from Psychiatric Hospitalization

           259,930

Arturas Petronis

Centre for Addiction and Mental Health

Department of Psychiatry

The Aging Brain: Circadian, Transcriptomic, and Epigenomic Dimensions

        1,085,591

Khosrow Adeli

Hospital for Sick Children

Department of Laboratory Medicine & Pathobiology

Mechanisms of Diabetic Dyslipidemia: Neuroendocrine Regulation of Intestinal Lipoprotein Metabolism in Normal and Insulin Resistance States

           860,064

John H. Brumell

Hospital for Sick Children

Department of Molecular Genetics

Proteomic studies of autophagy and its defects in Inflammatory Bowel Disease

           642,180

Brian G. Ciruna

Hospital for Sick Children

Department of Molecular Genetics

Applying unique zebrafish models to elucidate and functionally validate the molecular genetic causes of adolescent idiopathic scoliosis

           909,755

Jayne S. Danska

Hospital for Sick Children

Department of Immunology

Mechanisms of Inflammation, Immunity and Islet Dysfunction in Diabetes (MI3D)

        1,563,404

James Dowling

Hospital for Sick Children

Department of Paediatrics

Unraveling the genetics of malignant hyperthermia

           955,625

Sean E. Egan

Hospital for Sick Children

Department of Molecular Genetics

Chromosome 16q, a Cancer Suppressor Chromosome Arm

           741,565

Chi-Chung Hui

Hospital for Sick Children

Department of Molecular Genetics

Genetic mouse models of SHH medulloblastoma for molecular analysis and therapeutics

           852,420

Sheena A. Josselyn

Hospital for Sick Children

Department of Physiology

Examining the neural basis by which environmental stimuli acquire biological significance

        1,051,189

Jean-Philippe Julien

Hospital for Sick Children

Department of Biochemistry

Structural delineation of B cell co-receptors.

           947,980

David R. Kaplan

Hospital for Sick Children

Department of Molecular Genetics

Identification of novel druggable axon degeneration pathways

           393,717

Peter K. Kim

Hospital for Sick Children

Department of Biochemistry

Function and Regulation of Peroxisomes in Health and Disease

           753,035

Julie L. Lefebvre

Hospital for Sick Children

Department of Medical Biophysics

Regulation of inhibitory interneuron development and circuit assembly by Protocadherins

           860,064

Christopher K MacGowan

Hospital for Sick Children

Department of Medical Biophysics

Dynamic 3D MRI of the fetus: a new method for detecting abnormal blood flow and oxygenation during pregnancy

           542,795

Sanjay Mahant

Hospital for Sick Children

Department of Paediatrics

Intermittent vs. Continuous Oxygen Saturation Monitoring in Infants Hospitalized for Bronchiolitis: A Randomized Controlled Trial

           607,778

Roman Melnyk

Hospital for Sick Children

Department of Biochemistry

Development of a Novel Platform to Treat Neuropathic Lysosomal Storage Diseases

           672,761

Michael F. Moran

Hospital for Sick Children

Department of Molecular Genetics

Cancer target discovery and validation in the stromal phospho-proteome

           860,064

Martin Offringa

Hospital for Sick Children

Department of Paediatrics

Development, validation and implementation of a reporting guideline for the selection and measurement of outcomes in clinical trials

           344,025

Christopher E. Pearson

Hospital for Sick Children

Department of Molecular Genetics

Nucleic acid-binding ligands as modulators of repeat instability for therapeutic benefit against neurological and neuromuscular diseases

        2,293,500

Daniela Rotin

Hospital for Sick Children

Department of Biochemistry

Regulation of mTORC1 by LAPTM4b and the Leu transporter

           726,275

Michael T. Seed

Hospital for Sick Children

Department of Paediatrics

Brain development following late onset intrauterine growth restriction

           550,440

Michael T. Seed

Hospital for Sick Children

Department of Paediatrics

The haemodynamics of intrauterine growth restriction

           676,584

Michael D. Taylor

Hospital for Sick Children

Department of Surgery

Broad deletions of chromosome 17p constitute a therapeutically targetable driver event in medulloblastoma

           955,625

Michael D. Taylor

Hospital for Sick Children

Department of Surgery

Medulloblastoma Metastases are Hematogenous, and Driven by Expression of CCL2

           993,851

Michael D. Wilson

Hospital for Sick Children

Department of Molecular Genetics

Functional and evolutionary dissection of vascular endothelial cell responses to Inflammation

           760,680

Erin Kennedy

Mount Sinai Hospital

Department of Surgery

Phase II study to assess the safety of non-operative management (NOM) for low rectal cancer (LRC)

           405,185

Jennie Johnstone

Ontario Agency for Health Protection and Promotion

Department of Medicine

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

        1,272,893

Andras Kapus

St. Michael's Hospital

Department of Surgery

Characterization and cytoskeletal regulation of nucleocytoplasmic traffic and expression of mechanosensitive transcription factors. Relevance to organ fibrosis

           665,115

General Leung

St. Michael's Hospital

Department of Medical Imaging

Development of the MultIspectral MObile tiSsue Assessment (MIMOSA) device

           386,072

John C. Marshall

St. Michael's Hospital

Department of Surgery

Regulation of Neutrophil (PMN) Inflammatory Function by Caspase-8 Phosphorylation

           676,584

Laurie Morrison

St. Michael's Hospital

Department of Medicine

The Surviving Opioid Overdose with Naloxone Education and Resuscitation (SOON-ER) trial: a randomized study of an opioid overdose education and naloxone distribution intervention for laypeople in ambulatory and inpatient settings

           844,772

Joel G. Ray

St. Michael's Hospital

Department of Medicine

Using novel population-based datasets to produce and implement clinical prediction models for preterm preeclampsia, stillbirth, maternal ICU and long-term cardiovascular disease among Canadian women

           336,380

Richard Aviv

Sunnybrook Health Sciences Centre

Department of Medical Imaging

Testing existing and new therapeutic interventions in a novel animal model of acute Spot Positive intracranial hemorrhage

           722,454

Nick Daneman

Sunnybrook Health Sciences Centre

Department of Medicine

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial

        2,010,635

Jean Gariepy

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Understanding and harnessing the therapeutic potential of VISTA: a PD-1-like negative immune checkpoint regulator

           756,855

Dennis Ko

Sunnybrook Health Sciences Centre

Department of Medicine

Reducing Readmission after Acute Coronary Syndrome Hospitalization by Identifying Important Determinants and Effective Strategies to Improve Care

           470,169

Avril Mansfield

Sunnybrook Health Sciences Centre

Department of Physical Therapy

Promoting Optimal Physical Exercise for Life (PROPEL) - aerobic exercise and self-management early after stroke to increase daily physical activity: a randomized trial

           554,264

Robert A. Screaton

Sunnybrook Health Sciences Centre

Department of Biochemistry

Establishing a Comprehensive Genetic Roadmap for Human Pancreatic Beta Cell Proliferation and Function

           764,500

Baiju R. Shah

Sunnybrook Health Sciences Centre

Department of Medicine

Derivation of risk prediction models and a computer microsimulation model in type 2 diabetes to aid clinical decision making and health technology assessment

           424,298

Greg J. Stanisz

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Evaluation of Brain Metabolites Following Microbiotic Diet. Quantitative Assessment of glutamate, GABA and serotonin using Magnetic Resonance Spectroscopy and Chemical Exchange Saturation Transfer

           894,465

Hannah Wunsch

Sunnybrook Health Sciences Centre

Department of Anesthesia

Opioid use after critical illness

           183,480

Slava Epelman

UHN - Toronto General Hospital

Department of Medicine

Primitive cardiac macrophages and their reparative role following ischemic injury

           917,400

Jason E. Fish

UHN - Toronto General Hospital

Department of Laboratory Medicine & Pathobiology

Contribution of circulating microRNAs to the etiology of vascular disease

           684,229

John S. Floras

UHN - Toronto General Hospital

Department of Medicine

Identifying reflex sympatho-excitatory targets in heart failure to improve exercise capacity

           321,091

Benjamin Haibe-Kains

UHN - Princess Margaret Hospital

Department of Medical Biophysics

Development of drug combinations in acute myeloid leukemia

           340,203

Naoto Hirano

UHN - Princess Margaret Hospital

Department of Immunology

Novel CAR-T cell therapy targeting a Wilms Tumor 1 peptide presented by multiple HLA-DP alleles

           688,051

Douglas S. Lee

UHN - Toronto General Hospital

Department of Medicine

BaSIS Risk Score for Primary Prevention Implantable Cardioverter Defibrillators

           592,488

Mingyao Liu

UHN - Toronto General Hospital

Department of Surgery

Prevention of primary graft dysfunction after lung transplantation; a bench to bedside approach

           787,435

Aylin Y. Reid

UHN - Toronto General Hospital

Department of Medicine

Role of inflammation in experimental post-traumatic epilepsy

           412,832

Lena Serghides

UHN - Toronto General Hospital

Department of Immunology

HIV antiretroviral exposure in early pregnancy - assessing the impact on progesterone mediated decidual development and function.

           676,584

Joan E. Wither

UHN - Toronto Western Hospital

Department of Medicine

Identification of the immunologic basis for production of pathogenic autoantibodies in Systemic Lupus Erythematosus

           764,500

Brad Wouters

UHN - Princess Margaret Hospital

Department of Radiation Oncology

Hypoxic regulation of DICER influences metastasis, stemness, tumour regrowth and reveals new opportunities for therapy

           764,500

Gelareh Zadeh

UHN - Toronto Western Hospital

Department of Surgery

Molecular characterization of radiation induced meningiomas

           493,104

Gang Zheng

UHN - Princess Margaret Hospital

Department of Medical Biophysics

A new treatment platform for glioblastoma: Ultrasound-mediated in situ conversion of porpyrin microbubbles to theranostic nanoparticles

           707,164

Dina Brooks

Campus

Department of Physical Therapy

Randomized controlled trial of balance training for fall reduction in individuals with COPD

           902,111

Patricia L. Brubaker

Campus

Department of Physiology

Mechanisms dictating the actions of glucagon-like peptide-2, a unique therapeutic for intestinal disorders

           764,500

Leah E. Cowen

Campus

Department of Molecular Genetics

Identifying Vulnerabilities in Fungal Pathogens Through Functional Genomic and Chemical Genomic Analysis of Essential Genes

        1,288,184

Brian J. Cox

Campus

Department of Physiology

Functions of miRs in the nucleus during cell fate development

           672,760

Alexander W. Ensminger

Campus

Department of Biochemistry

Studying CRISPR-Cas to identify modulators of a waterborne pathogen's fitness

           554,264

Andrew G. Fraser

Campus

Department of Molecular Genetics

Using C.elegans to identify drugs that target a metabolic pathway that is essential for parasitic helminths but absent from humans

           947,980

Herbert Gaisano

Campus

Department of Medicine

Alpha-cell glucagon secretion: regulated exocytosis, dysregulation & rescue of type-1 diabetes

           783,615

Susan R. George

Campus

Department of Pharmacology & Toxicology

A dopamine receptor complex mediates susceptibility to depression with enhanced effect in females

           909,755

Stephen E. Girardin

Campus

Department of Laboratory Medicine & Pathobiology

NLRX1 in the control of epithelial proliferation and intestinal tumorigenesis

        1,016,785

Jennifer L. Gommerman

Campus

Department of Immunology

The impact of TNF family cytokines on host-microbiome interactions in the context of a chronic kidney disease

           745,389

Jack F. Greenblatt

Campus

Donnelly Centre

Characterization of a gene regulatory pathway involving proteins mutated in SMA, ALS, and FTD

           764,500

Jack F. Greenblatt

Campus

Donnelly Centre

Mechanisms of gene regulation by the human C2H2 zinc finger proteins and interacting RNAs

        1,058,835

Walid A. Houry

Campus

Department of Biochemistry

The role of the ClpP protease in bacterial pathogenesis

           802,725

Thierry R. Mallevaey

Campus

Department of Immunology

The relationship between iNKT cells & the microbiota in the control of intestinal inflammation

           542,795

Sunita Mathur

Campus

Department of Physical Therapy

Evaluation of Sarcopenia in Solid Organ Transplantation

           236,995

Jane A. Mitchell

Campus

Department of Pharmacology & Toxicology

Variation in G protein expression in bone cells determines bone quality and response to catabolic and anabolic stimuli

           504,571

Jason Moffat

Campus

Donnelly Centre

Systematic co-targeting of receptor tyrosine kinases for cancer

           768,324

Trevor F. Moraes

Campus

Department of Biochemistry

Elucidating the Mechanism of SLAM dependent Surface Lipoprotein Translocation in Gram Negative Bacteria

           688,051

Sachdev S. Sidhu

Campus

Donnelly Centre

Inhibitors of viral pathogenic deubiquitinases

           840,951

Anurag Tandon

Campus

Centre for Research in Neurodegenerative Diseases

Non-invasive gene therapy for Parkinson's disease and other synucleinopathies

           978,560

Andrew R. Wilde

Campus

Department of Molecular Genetics

The role of anillin in modulating the cytoskeleton of dividing and differentiated cells

           611,600

Min Zhuo

Campus

Department of Physiology

Insular cortex in chronic pain and its related anxiety

           707,164

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