Planning Means Hand/Arm Transplants Available to More Canadians

The surgery itself may have taken 14 hours, but the groundwork for it began five years earlier. It was announced this week that a 49-year-old woman was the recipient of a new hand and forearm through a still rare type of surgery performed at UHN’s Toronto Western Hospital. Known as Vascularized Composite Allotransplantation – or VCA – it’s an emerging field of surgery that blends transplant surgery and microsurgery.

Professor Ronald Zuker of the Department of Surgery saw the promise it could deliver. With early successes in the United States and Europe, Zuker – who is also a plastic and reconstructive surgeon at The Hospital for Sick Children – established a committee to investigate the procedure.

“Initially we wanted to be able to respond to questions from patients and their families, as well as stay up-to-date on the field,” said Zuker. However the committee soon began mapping out how this surgery could be delivered locally. In addition to collaborating closely with colleagues at SickKids and UHN, the group also worked with government officials and the Trillium Gift of Life Network to develop the protocols and reviews that were necessary before the surgery could be introduced in Toronto.

“As we went through that process, we managed to put together a team at U of T so we could do this,” said Zuker. “We would reach out to specialists in other areas who could lend their expertise and perspective to different issues we would face. It helped us identify the team of people available who were interested and who wanted to be involved.”

At its core, VCA needs a transplant team – who can focus on maintaining the viability of the limb and overcoming immune or infection issues – and a team of micro-surgeons – who connect the vascular and nervous systems. But in addition, specialized anesthesiologists, nurses, pharmacists and rehabilitation specialists are required to ensure the surgery is a success.

With the right people in place, and with government approval in hand, the team was ready to find the right patient. A suitable donor couldn’t be found for the first patient put on the list and he was eventually removed. The second patient added was the woman who successfully underwent the procedure and is now recovering. Zuker anticipates with news of the surgery now spreading, new patients will soon come forward.

“Our aim is to help those patients who are having a difficult time using their prosthesis,” he said. “For those who are managing with their assistive devices, the benefits of this surgery may not be optimal. But for those patients who need a better option – such as double amputees – we are able to provide a new alternative for them.”

For now, donors need to be located near the recipient patients. Zuker explained that there is only a six-hour window where muscle – especially those in the hand and arms – can go without blood circulation before it starts to deteriorate. However, new technology is being developed that could increase that window to 12 to 14 hours. That would allow donors to be identified from across Ontario – and possibly the country.

He is also optimistic that the groundwork done by the U of T team will open the door for other medical centres in Canada to follow suit.

“We’re confident that the work we have done will mean this type of surgery will be available to more Canadians going forward,” Zuker said.