Department of Pharmacology and Toxicology Seminar - Emerging Roles of Cytochrome P450 Family 4 Enzymes in Cancer

Friday, July 28, 2017 - 13:00 - 14:00

Among the human CYP4 enzymes, members of the cytochrome P450 (CYP), 4A and 4F sub-families have attracted the greatest attention because of their roles in the metabolism of endogenous fatty acids and some drugs. Much less is known about CYP4B and CYP4Z enzymes, but recent studies highlight new potential roles for these enzymes as a suicide gene for adoptive T-cell therapy and biomarker for breast cancer progression, respectively. This lecture will provide background on the biochemistry of CYP enzymes and discuss recent findings on the engineering and substrate selectivity of human CYP4B1 and CYP4Z1.

Dr. Allan E. Rettie, Professor of Medicinal Chemistry, University of Washington, Seattle, WA
Dr. Rachel Tyndale, Professor, Department of Pharmacology and Toxicology
Medical Sciences Building, Room 4279
1 King's College Circle
M5S 1A8
Elaine Jack |
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